Francis died on April 26 at 88 years old.
Pope Francis, the 266th pope of the Roman Catholic Church, will be buried Saturday at the Basilica of Saint Mary Major after dying one week ago at 88 years old.
Francis, who took his name after Saint Francis of Assisi, was known for his outreach to the poor and those in poverty and that will be reflected in his minimalist burial at Saint Mary Major. He is the first pope to be buried outside the Vatican in over a century and the first to be buried at Santa Maria Maggiore in more than 300 years.
Watch ABC News' live coverage of the funeral for Pope Francis now on ABC stations and streaming on ABC News Live, Disney+ and Hulu.
Tap on the blue circle to take a look at photos from the funeral for Pope Francis.
KABC's David Ono shares the crowd's reaction to seeing the Popemobile carrying Pope Francis' casket as it makes its way from St. Peter's Basilica to its final resting place of Rome's Basilica of Saint Mary Major.
"I'm watching people be emotional and wipe their eyes ... You know, it is that very human thing. You want to celebrate his life but you mourn his loss."
Tens of thousands of people have lined the four-mile route between St. Peter's Basilica and Rome's Basilica of Saint Mary Major, where Pope Francis will be laid to rest this afternoon.
People could be seen crying and applauding the vehicle carrying his coffin as thousands took the final opportunity to thank Pope Francis.
The procession is taking the pope's body past a number of Rome's historical landmarks, including the Roman Forum and the Colosseum.
When Pope Francis arrives at Rome's Basilica of Saint Mary Major, it will be the last time he will be seen in public before he is buried, and the basilica reopens to visitors again on Sunday.
Crowds applauded and yelled "Papa Francesco!" as a slow-moving motorcade escorting the pope's coffin to his final resting place left the Vatican to make its way across Rome.
The coffin was visible from atop a modified popemobile. There was more clapping and church bells rang out as the popemobile emerged from a tunnel and crossed the Tiber River.
The popemobile was flanked by police on motorcycles.
The 3.5-mile route crosses the Tiber River and passes Italy's monumental Tomb of the Unknown soldier, the ancient Roman Forum and the Colosseum before reaching the basilica.
The coffin will be met by about 40 migrants, prisoners, and homeless and transgender people, reflecting the pontiff's care for people who are marginalized.
The coffin carrying Pope Francis was carried through the Holy Door of St. Peter's Basilica for a final time on Saturday morning as bells tolled for the pope throughout the Vatican.
The funeral, lasting over two hours, concluded with bells ringing for the pontiff as tens of thousands gathered to mourn.
Pope Francis' coffin will now be taken to Rome's Basilica of Saint Mary Major where he will be laid to rest.
