Authorities responded around 1:10 p.m. Thursday to the Route 30 Bypass in Sadsbury Township
The view from Chopper 6 showed the tractor-trailer hanging off the highway onto Old Mill Road.
A green tractor was also damaged in the incident.
There was no immediate word on the condition of the injured victim.
The westbound lanes were closed for several hours. The scene wasn't clear until around 5 p.m.
Further details on the crash have not been released.