It happened just after 1:30 a.m. Sunday on the 1200 block of Lehigh Avenue.
When officers arrived, they found 32-year-old Nafeece Acquil Jenkins unresponsive in the road.
He died at the scene.
Police say they believe a white Honda was traveling at a high rate of speed when it struck Jenkins as he was crossing the road.
The vehicle was later located unattended in a lot on the 1200 block of Park Avenue.
Police continue to investigate.