Police told Action News overnight that the motorcycle had been stolen.
The collision happened just after 9 p.m. Wednesday on the northbound lanes of Roosevelt Boulevard at Comly Road.
Authorities say a motorcycle collided with a minivan, killing a man and a woman who were riding on the motorcycle. Their identities have not yet been released.
The driver of the minivan was transported to Jefferson Torresdale Hospital with non-life-threatening injuries.
Police say they were not pursuing the motorcycle at the time of the crash.
The cause of the crash remains under investigation.