The gunfire erupted on 43rd Street, near Pennsgrove Street, around 11:23 p.m. Wednesday.
A 54-year-old woman was shot in the shoulder and is hospitalized in stable condition.
A 38-year-old man was hit in the abdomen and is hospitalized in critical condition.
A police real-time crime camera shows the gunfire came from a gray Dodge Durango with one headlight out.
Anyone with information is asked to call or text Philadelphia police at 215-686-TIPS (8477) or submit an anonymous tip online.
RELATED: Check the 6abc Neighborhood Safety Tracker