It happened around 2 a.m. Thursday in the 4400 block of Sheffield Avenue.
Police say a 13-year-old boy was entering his home through the basement when he was followed inside by two suspects.
He was held at gunpoint and told to open a safe.
The suspects then fled the scene with multiple weapons.
No arrests have been made.
Anyone with information is asked to call or text Philadelphia police at 215-686-TIPS (8477) or submit an anonymous tip online.
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