The incident happened just after 5:30 p.m. Thursday on the 5600 block of Arch Street.
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Police say a 14-year-old male was shot once in the back.
The teen was transported by police to Children's Hospital of Philadelphia in critical condition.
A second victim, a 17-year-old male, was shot twice in the head.
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He was transported by police to Penn Presbyterian Medical Center and is listed in critical condition.
Police are looking into whether the 14-year-old was struck by stray gunfire. They say the 17-year-old appeared to be the intended target.
No weapons were recovered from the scene, police say.
No arrests have been made at this time.